Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

You can’t keep a good mitochondrion down. Or maybe you can. In today’s Cell, researchers led by Zu-Hang Sheng at the National Institute for Neurological Disorders and Stroke report that the protein ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Carnegie Mellon University's Jessica Zhang and Angran Li have developed a new way to model material transport regulation in neurons, focusing on the "traffic jams" that occur in these neural pathways.

A mutation in the TDP-43 protein reduces the viability of motor neurons without triggering protein clumps, researchers found.

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...