UniQure faces a setback as the FDA demands a placebo-controlled study for its Huntington's gene therapy, rejecting the recent trial design that lacked randomized control. The FDA remains firm on its ...

When Elise Felicione tried to design a clinical trial for a supplement, 5 things got in the way. It’s a lesson for the ...

However, traditional clinical trial designs are often ill-suited for rare disease research with common challenges including ...

“Well, we don’t have as much evidence as we would like on steroid use during pregnancy,” the obstetrician warned my co-author, Natalia Emanuel, as she wrote a prescription for inhaled corticosteroids ...

The GoGoVax randomized controlled trial found that 4CMenB does not reduce gonorrhoea incidence in high-risk gay and bisexual ...

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...

A 5-day amoxicillin challenge was feasible for evaluating delayed penicillin allergy, with more than 80% of participants completing the protocol; immune‑mediated reactions were uncommon but occurred ...