Researchers at University of Tsukuba have achieved high-resolution visualization of cellular organelles, such as nuclei and mitochondria, using an external apodized phase contrast (ExAPC) microscope.

The use of high-resolution bright-field microscopy is essential for cellular-scale biological research, but this technique has limitations due to low image contrast. Using dyes on the sample can ...

Until today, skin, brain, and all tissues of the human body were difficult to observe in detail with an optical microscope, since the contrast in the image was hindered by the high density of their ...

Unprecedented views of the interior of cells and other nanoscale structures are now possible thanks to innovations in expansion microscopy. The advancements could help provide future insight into ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...

Living organisms are complex systems with scales of organization spanning the range from Angstroms to meters. Even when consideration is limited to single cells and smaller, there is still a range of ...