In reading, a bookmark tells where you stopped. Cells use bookmarks too, specific proteins that help the cell remember what collection of genes needs to be turned on again after the brief halt of gene ...

Using participant skin cells reprogrammed into neurons, Weill Cornell Medicine researchers have identified genetic signatures ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

Mitochondrial transfer is known to occur from the tumor microenvironment into cancer cells, but now, Swiss researchers have shown a possible precursor to this is that cancer cells smuggle their ...

This diagram illustrates how the combination of fibroblast growth factor 4 and ascorbic acid activates the JAK2–STAT3 signaling pathway, promoting the maturation of induced cardiomyocytes (iCMs). This ...

Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since ...

Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refining data, conducting massive trials, before unveiling results that altered the ...

Life begins with a tiny orchestra of stem cells, setting the stage for the body’s grand symphony of development. As the performance unfolds, a dynamic interplay of factors takes center stage, ...

Piezo2 is increased in idiopathic pulmonary fibrosis (IPF). Immunohistochemistry of nonfibrotic (left) and IPF (right) lung tissue demonstrating that Piezo2 (brown staining) is strongly present in ...