A new computational study led by University at Buffalo scientists and published April 21 in Biophysical Journal sheds light ...

A review maps high throughput strategies that link automation, microfluidics, and barcoding into a unified pipeline, enabling faster, more predictive lipid nanoparticle development for genetic ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Researchers have developed a new lipid nanoparticle design that directs mRNA to the pancreas by exploiting the organ’s own filtration barrier, a strategy that sidesteps the liver-trapping problem that ...

Postdoctoral fellow and co-first author Dongyoon Kim demonstrates some of the equipment used to craft the new ionizable lipids. The most common side effects of mRNA vaccines like the COVID-19 shot are ...

Using artificial intelligence (AI), researchers headed by a team at Massachusetts Institute of Technology (MIT) have come up with a new way to design nanoparticles that can more efficiently deliver ...

Cell membranes are more than just barriers—they are dynamic, multifunctional structures essential for life. From controlling what enters and exits the cell to enabling communication and repair, they ...

“We’ve never had such an in-depth map of the CD1 lipidome available,” said Patricia Barral, an immunologist at King’s College London who was not involved with the work. “It will enable us to start ...