A cell has many ways to regulate gene expression, one of which is the structure of the genome itself; active genes have to be accessible to the cellular machinery to be expressed. The DNA in the ...
When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...
TOP2A relieves negative supercoiling at gene promoters, resulting thus in an increase in the number of twists of the DNA strands. This is an obstacle to the continuous opening of the helix that ...
Coiled tertiary structure that forms when strain is placed on a DNA helix by overwinding or underwinding of the helix. An overwound DNA exhibits positive supercoiling; an underwound DNA exhibits ...
The (when stretched) two-meter-long DNA molecule in each human cell is continuously being unpacked and packed again to enable the expression of genetic information. When genes must be accessed for ...
The transcribing RNA polymerase induces torsional strain in the DNA; in front of the polymerase, DNA is overwound (referred to as positive supercoiling), and behind it DNA is underwound (referred to ...
When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...
When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...
Supercoiling and looping can transmit mechanical stress along the DNA backbone that can promote the separation of the strands of the double helix at specific distant sites, exposing the DNA bases, ...
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