Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

A research team at The University of Osaka revealed that the loss of heterochromatin can cause a chain reaction leading to ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

From a genetic perspective, the formation of an R-loop is a critical risk for bacteria. An R-loop occurs when newly ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 50 (December 13, 2022), pp. 1-12 (12 pages) R-loops, or RNA:DNA hybrids, can induce DNA damage, which ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...