Sumoylation, the covalent attachment of small ubiquitin-like modifiers (SUMOs) to target proteins, plays a pivotal role in regulating plant development and stress responses. This post-translational ...
The diagram illustrates the SUMOylation pathway, including its key steps: maturation, activation, conjugation, ligation, and de-modification. The process begins with SUMO precursors undergoing ...
Cells, are you experiencing stress? Quick, SUMOylate your TDP-43 before it’s too late! Three independent papers appearing in rapid succession deliver the same message: Chain the small ubiquitin-like ...
Scientists are expanding strategies for targeting misfolded tau. At this year’s AD/PD conference, held March 5 to 9 in Lisbon, Portugal, speakers highlighted a protein modification ...
The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies. As a SUMO E3 ligase, RANBP2 plays a pivotal role in ...
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