Researchers identify the Munc13-1 protein as a crucial molecular pathway for working memory, linking calcium signaling to ...

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia. How this happens remains largely ...

Neurobiologists have uncovered the long-sought-after mechanisms behind the maintenance and decline of key synapses implicated in brain disorders such as Alzheimer's disease. The researchers identified ...

New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications ...

An interdisciplinary team of scientists at the Max Planck Florida Institute for Neuroscience have developed a novel approach to measure the activity and strength of individual synapses that drive a ...

The death of synapses, and the neurons that need them, marks the inevitable endgame of Alzheimer’s disease. Despite this eventual synaptic mayhem, a new work, led by Thomas Südhof and Marius Wernig at ...

Neuroscientists say they have found a new function for the SYNGAP1 gene, a DNA sequence that controls memory and learning in mammals, including mice and humans. Johns Hopkins Medicine neuroscientists ...

Family with sequence similarity 19 member A5 (FAM19A5) is a secretory protein highly expressed in the brain that regulates synapse dynamics through its interaction with leucine-rich repeat-containing ...

Both presenilin-1 or the less-studied presenilin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...