Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

In early 2021, as COVID-19 vaccines were being rolled out across the world, reports began to surface of a rare but alarming complication. Some people who received the shots were developing unusual ...

With so many artificial intelligence (AI) products on offer now, it’s increasingly tempting to offload difficult thinking tasks to chatbots, agents and other tools. As we chart this new technological ...

Over the past decade, however, a wave of technological advances has begun to expand the druggable proteome. These include covalent inhibitors (such as sotorasib), chemical proteomics, and AI-enabled ...

A single intramuscular injection of a self-amplifying RNA therapy produced weeks of heart-protective protein in rat models of myocardial infarction, according to a study published in Science on March ...

Scientists reprogrammed two widely used “chemically induced proximity” systems in a recent chemical science paper. CIP systems are very simple: when a small molecule is added, two engineered protein ...

Researchers at the University of California San Diego have identified new genetic variants associated with autism spectrum ...

Researchers at the University of California San Diego have identified new genetic variants associated with autism spectrum disorder (ASD) by using long-read whole genome sequencing (LR-WGS), an ...

Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and ...