This important paper presents a rigorous and comprehensive deep mutational analysis of the kinase TYK2, revealing how single amino acid substitutions influence protein abundance, signaling activity, ...

As skiers, the longer we can go without riding a chairlift or hitting the skin track, the better. Uninterrupted skiing is the Holy Grail, and some ski resorts—primarily those with considerable acreage ...

Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...