eLife

Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes

This important study analyzed the impact of amino acid homorepeats on protein expression and solubility in yeast and E. coli. The authors provided convincing evidence that hydrophobic and positively ...
IEEE

Federated Aggregation With Interlayer Personalized Contribution: Preference-Based Optimization Between Performance and Privacy

Abstract: Currently, due to the different distribution of data for each user, many personalized federated learning (PFL) methods have emerged to meet the personalized needs of different users. However ...
IEEE

PriRoAgg: Achieving Robust Model Aggregation With Minimum Privacy Leakage for Federated Learning

Abstract: Federated learning (FL), as a promising machine learning paradigm for large-scale distributed data, faces two security challenges of privacy and robustness: the transmitted model updates ...
eLife

Nuclear export governs TDP-43 phase transitions and cytoplasmic aggregation

This study presents valuable findings implicating nuclear export in the regulation of protein condensate behaviour and TDP-43 phase behaviour, suggesting a link to pathogenic aggregation in ALS/FTD.