When Elise Felicione tried to design a clinical trial for a supplement, 5 things got in the way. It’s a lesson for the ...

Researchers at The Hospital for Sick Children (SickKids), working with international collaborators and youth and family ...

A new study in the American Journal of Preventive Medicine reports findings from a randomized controlled trial—the gold standard study design in health research—showing that promoting drinking water ...

Abstract: Increased electric grid penetration of intermittent renewable energy sources has reduced the controllability of the generation side and created a need for more coordination between ...

The FDA is raising the bar for approval of CAR T-cell therapies in oncology. Under plans outlined by the FDA’s biologics chief Vinay Prasad, M.D., the agency will require developers of many CAR-Ts to ...

Abstract: Safety and data efficiency are important concerns in data-driven control, especially for nonlinear systems with unknown dynamics and subject to disturbances. In this work, we consider a ...

Recent randomized controlled trials (RCTs) in patients with prolonged disorders of consciousness (pDoC) have yielded limited success. Among them, only studies involving amantadine have provided Class ...

Methods: YOSEMITE is a phase 3, randomized, double-blind, placebo-controlled trial. Key inclusion criteria are genetically confirmed HoFH or a clinical diagnosis (total cholesterol >500 mg/dL OR ...

Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings ...

Introduction Schizophrenia is a severe mental disorder. While some antipsychotic medications have demonstrated efficacy in treating positive symptoms, there is no widely recognized treatment for ...

Electroconvulsive therapy (ECT) is one of the main strategies for major depressive disorder (MDD). Recently, the use of esketamine in the treatment of depression due to the rapid antidepressant ...

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...