Researchers built an open tool to handle complex genome sequencing data, offering automated quality control, improved variant detection, reduced false positives, and standardized workflows for easier, ...

Researchers discover leopard gecko produces females at cooler incubation temperatures and mostly males at warmer ones. This clear sex-determination pattern of leopard gecko has established it as a key ...

Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles ...

The origin of many diseases begins at the cellular level and involves multiple molecular interactions. However, previous methods have struggled to accurately observe changes in individual cells.

Scientists can peer into cells to get a limited view of their activity using microscopes and other tools. However, cells and the molecular events within them are dynamic, and developmental processes, ...

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571126, Hainan, People’s Republic of China Key Laboratory of Tropical Medicinal Plant ...

This session, part of the Statistical analysis in systematic reviews series, gave a short, non-technical, introduction to meta-analysis, which is the statistical method used for combining results ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

Identification of key transcription factors from transcriptome data by correlating gene expression levels with transcription factor binding sites is important for transcriptome data analysis. In a ...

Objectives Belimumab is a putative disease-modifying agent in systemic lupus erythematosus (SLE), yet the molecular underpinnings of its effects and the ability to predict early clinical response ...