Learn about comparative gene expression studies in Alzheimer's disease and other conditions in Mayo Clinic's Precision Medicine in Neurodegeneration Lab.

Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles ...

Researchers create a massive single-cell atlas of the aging mouse brain, revealing how epigenetic changes and "jumping genes" drive neurodegeneration.

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

A recent integrative analysis of single-cell sequencing and single-cell spatial mapping of lymph node metastasis in breast cancer reveals novel mechanisms of the metabolic-immune interaction that ...

Recent advances in neural circuit mapping—including viral tracing, high-resolution imaging, single-cell transcriptomics, and in vivo recordings—have greatly ...

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...

Breast cancer remains one of the most prevalent and life-threatening forms of cancer, impacting millions worldwide. This malignancy's heterogeneity and complexity have long posed significant ...

This is not incremental progress - it is a step-change that unlocks industrial-scale biology for drug discovery, toxicology, and AI-driven research. Our additional investment reflects our conviction ...

Understand the significance of proteo-transcriptomics in identifying vulnerabilities in Candida auris and addressing drug resistance.

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

Abstract: Spatial transcriptomics (ST) has become an important methodology in the analysis of the tumor microenvironment (TME) due to its ability to provide gene expression information with spatial ...