Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the …

More than 300 calmodulin-binding proteins (calmodulin targets) have been identified to date (representative examples are summarized in Fig. 1). Among these, calmodulin-dependent …

Calmodulin is a protein that binds to the intracellular face of GPCRs, such as the μ-opioid receptor, and helps in reducing GPCR signaling by affecting G-protein coupling.

Sep 9, 2024 · Calmodulin, a protein critically important for the regulation of all major cardiac ion channels, is the quintessential cellular calcium sensor and plays a key role in preserving …

Calmodulin also binds to phenothiazine drugs and related compounds in a calcium-dependent manner. While the physiological or pharmacological importance of many of these activities has …

Jun 15, 2024 · Calmodulin (CaM) modulates the sarcoplasmic reticulum Ca2+ release channel, the ryanodine receptor (RyR), to facilitate Ca2+ cycling in muscle contraction and release.

Calmodulin (CaM) is a small but vital protein that is able to rapidly transmit information about changes in Ca 2+ concentrations to its regulatory targets. CaM plays a critical role in cellular …

Feb 13, 2025 · Calmodulin is a calcium-dependent molecular switch, activated by the binding of four calcium ions to EF-hand motifs, resulting in the accessibility of previously hidden apolar …

Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the …

Jul 1, 2011 · We studied the reorientation of the two major domains of calmodulin and the flexibility of the tether. The simulations shed light on the time-dependent availability of various …