Myotonic dystrophy type 2 is caused by genetic mutations, also known as pathogenic variants. Genetic mutations can be hereditary, when parents pass them down to their children, or they …

Dec 12, 2022 · Myotonic dystrophy type 2: This form typically begins in adulthood. The average age of onset is 48 years. How common is myotonic dystrophy?

DM2 is an important diagnosis to consider in patients who have proximal muscle weakness around the shoulders and pelvis or a “limb-girdle weakness”. DM2 is an autosomal dominant …

Onset for DM2 ranges from the second to the seventh decade of life, often presenting with myotonia, weakness, or cataracts. In general, DM2 is a less severe disease than classic DM1.

As a result, people with multiple symptoms that may be explained by a complex disorder such as DM1 or DM2 will generally be referred by their primary care physician to a neurologist for …

DM2 is caused by the expansion of an unstable CCTG repeat sequence in intron 1 of the CNBP gene in chromosome 3q21.3. The normal number of CCTG repeats in this region is less than …

Jul 25, 2025 · Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are autosomal dominant, multisystem disorders characterized by skeletal muscle weakness and …

Myotonic dystrophy type 2 (DM2) is a genetic muscle condition causing progressive weakness, stiffness, and pain, with possible heart, lung, and digestive involvement. Learn about …

Mar 19, 2024 · There are two types of myotonic dystrophy: DM1 and DM2, and different genetic mutations cause each type. These mutations affect the muscle structure, leading to weakness …

Myotonic dystrophy (DM) includes two major types — DM1 and DM2 — both caused by genetic defects. They result in multisystem disorders characterized by skeletal muscle weakness and …