The integrated stress response (ISR) is an evolutionarily conserved intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable environment and maintain health.

The integrated stress response is a cellular stress response conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific genes in response to internal or …

Mar 26, 2025 · The integrated stress response (ISR) is an integral arm of the unfolded protein response that reprograms translation under a broad range of stresses 1.

Oct 1, 2025 · The integrated stress response (ISR) is an evolutionarily conserved signaling network that regulates protein synthesis in response to diverse cellular stressors to promote stress adaptation.

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.

Mar 28, 2025 · For decades, scientists believed that cells react to various stressors—such as starvation, infection by pathogens, heat, and iron deficiency—through a unified pathway known as the …

Nov 15, 2023 · The integrated stress response (ISR) refers to signaling pathways initiated by stress-activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including amino …