Its highly user-friendly environment makes it ideal not only for forecasting experiments, but also as an on-line tool for direct comparison of its simulations with incoming data.

PACE4: a subtilisin-like endoprotease with unique properties. PACE4 is one of the neuroendocrine-specific mammalian subtilisin-related endoproteases believed to function in …

Sep 1, 1994 · PACE4 mRNA levels in anterior pituitary are strikingly regulated by thyroid status, with more than a 10-fold increase seen from hypothyroid to hyperthyroid animals.

Apr 11, 2022 · The proprotein convertase PACE4 has demonstrated value as a viable therapeutic target in prostate cancer (PCa).

Apr 18, 2015 · Backgrounds: PACE4 is a proprotein convertase capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. However, the precise role of …

Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain. PACE4 is a member of the eukaryotic subtilisin-like …

The advantages of PACE4 calculations are the possibility to calculate gamma-emission and fission channels, to take into account the angular momentum (important for high excitation …

Our findings suggest that selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.

PACE4 / PCSK6 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or …

Recent studies have suggested that the family of enzymes known as the proprotein convertases (PCs) is involved in various types of cancers and their progression. The present study …